I looked up an address on Google Maps and noticed that the bridge over the River at Wabash was under construction, so I wikipedia'd the bridge's name, Irv Kupcinet Bridge. The first result: Perfect Strangers (TV series). In that article, I learned that the opening shot is of them going under the bridge in question. I also learned that Family Matters was actually a spinoff from Perfect Strangers: the mom, Harriette Winslow, worked in the elevator. Wow. Who knew?
Now if only I could find out about that bridge being under construction. :)